Hypocretinergic interactions with the serotonergic system regulate REM sleep and cataplexy
نویسندگان
چکیده
منابع مشابه
Challenging sleep homeostasis in narcolepsy-cataplexy: implications for non-REM and REM sleep regulation.
STUDY OBJECTIVES We recently proposed insufficient non-rapid eye movement sleep (NREMS) intensity to contribute to disturbed nocturnal sleep in patients with narcolepsy-cataplexy (NC). To test this hypothesis, we investigated the effect of physiologically intensified NREMS in recovery sleep following sleep deprivation. DESIGN Nocturnal baseline and recovery sleep architecture, and the sleep e...
متن کاملControl of trigeminal motoneuron behavior and masseter muscle tone during REM sleep, REM sleep behavior disorder and cataplexy/narcolepsy
Sleep markedly affects fundamental mechanisms of motor control. Sleep not only suppresses postural muscle tone (Brooks and Peever, 2008b; Burgess et al., 2008), but it also attenuates, and in some cases even abolishes motor reflexes (e.g., H-reflex) (Wills and Chase, 1979). Mechanisms of motor control are also differentially affected by prevailing behavioral state. For example, muscle tone and ...
متن کاملThe hypocretins (orexins) mediate the “phasic” components of REM sleep: A new hypothesis
In 1998, a group of phenotypically distinct neurons were discovered in the postero-lateral hypothalamus which contained the neuropeptides hypocretin 1 and hypocretin 2 (also called orexin A and orexin B), which are excitatory neuromodulators. Hypocretinergic neurons project throughout the central nervous system and have been involved in the generation and maintenance of wakefulness. The sleep d...
متن کاملA Case of REM Sleep Behavior Disorder, Narcolepsy-Cataplexy, Parkinsonism, and Rheumatoid Arthritis
A patient is reported in whom signs and symptoms of REM sleep behavior disorder (RBD) and narcolepsy have been associated for almost two decades with a late development of parkinsonism and rheumatoid arthritis. A 78-year-old male patient in whom RBD was first diagnosed was followed-up by clinical examination, video-polysomnography, multiple sleep latency test, cerebral magnetic resonance imagin...
متن کاملCells of a common developmental origin regulate REM/non-REM sleep and wakefulness in mice.
Mammalian sleep comprises rapid eye movement (REM) sleep and non-REM (NREM) sleep. To functionally isolate from the complex mixture of neurons populating the brainstem pons those involved in switching between REM and NREM sleep, we chemogenetically manipulated neurons of a specific embryonic cell lineage in mice. We identified excitatory glutamatergic neurons that inhibit REM sleep and promote ...
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ژورنال
عنوان ژورنال: Nature Communications
سال: 2020
ISSN: 2041-1723
DOI: 10.1038/s41467-020-19862-y